Kidney Transplant in Indore at Kokilaben Hospital

Kidney Transplant

The Nephrology and Urology departments boast the large dialysis units in the city, a sizeable and comprehensive renal transplant program, having performed both living and cadaveric transplants.

The success of the service is driven by strict infection control measures, well-structured immunosuppressive protocols, and proactive monitoring to swiftly manage complications. The Transplant Unit also takes a comprehensive approach by assessing and addressing the health needs of both the transplant patient and their family.

Acute renal failure is a reversible condition that occurs as a result of direct damage to the kidneys. Chronic Kidney Failure refers to the gradual and progressive decline in kidney function over time.

  • Chronic kidney disease is characterized by the presence of an identifiable kidney function abnormality or a screening marker like protein in the urine, along with reduced kidney function lasting for three months or more.
  • There are many causes of CKD. The kidneys are most commonly affected by diseases, such as diabetes and high blood pressure.
  • Some kidney conditions are passed down through families, while others are congenital, meaning individuals are born with abnormalities that can impact their kidneys.

End-stage kidney disease (ESKD) occurs when almost all kidney function is lost. Ultrasound imaging typically shows the kidneys as small and shrunken. At this stage, the kidneys are essentially non-functional for practical purposes.Lifelong dialysis or transplantation becomes mandatory for survival. Around 350,000 - 400,000 people develop ESKD each year.

Kidney disease usually affects both kidneys.

When the kidneys' ability to filter blood is significantly impaired by disease, waste products and excess fluids can accumulate in the body. While many types of kidney disease may not show symptoms until the later stages, there are six key warning signs to watch for.

  • Swelling of hands and feet, puffiness around eyes
  • More frequent urination, particularly at night. Difficult or painful urination.
  • Blood and/or protein in the urine
  • High blood pressure
  • Elevated levels in a Creatinine and Blood Urea Nitrogen (BUN) blood test indicate impaired kidney function. Both creatinine and BUN are waste products that accumulate in the bloodstream when the kidneys are not functioning properly.

There are only two options for End Stage Kidney Disease:

  • Life Long Dialysis
  • Kidney Transplantation

What is dialysis?

  • This process eliminates waste products and helps regulate the volume and composition of body fluids, which is a critical and essential function of the kidneys.
  • However, it does not assist with blood production or the activation of vitamin D, as normal kidneys would.Hence supplementary therapy is required
  • It does not improve diseased kidneys

What are the types of dialysis?

There are two different kinds of dialysis:

  • Haemodialysis, when the blood is cleaned outside the body through a machine
  • Peritoneal dialysis, when the cleaning is done inside the body using the peritoneal membrane

On certain occasions, medical reasons may necessitate choosing one kind of dialysis over the other. This is something a Nephrologist can best judge for the patient.

What is the best option for treatment of ESKD?

Kidney (Renal) Transplantation is known as the best form of treatment for ESKD due to the below reasons:

  • More cost effective
  • Enables a more normal lifestyle
  • Improved survival

How does the survival rate of patients on dialysis or after transplantation compare to that of the general population?

The transplant patient in any age group has a better life expectancy as compared to the dialysis patients. In which patients who undergo dialysis and as compared have 10 years more life expectancy rate.

Who is eligible for transplantation?

  • All patients with ESKD must be evaluated for suitability of kidney transplantation
  • Patients suffering from cancer or other infections are not eligible for transplantation

Some groups of patients need further evaluation:

  • Old age
  • Severe heart disease, lung disease or liver disease
  • HIV positive patients
  • Psychiatric illness

Where do the kidneys come for transplantation from?

Living Donors

Indian law allows close relatives to donate organs such as the kidney, liver, and bone marrow. Parents, siblings, children, grandparents, and spouses are considered near relatives. If a family member is unable to donate a kidney due to blood group incompatibility, and another pair faces a similar issue, the donors may be exchanged to facilitate kidney transplantation.

This is called a Swap Transplant

Living donors are thoroughly investigated by the physician. The donors should be in good overall physical and mental health and free from uncontrolled high blood pressure, diabetes, cancer, HIV, hepatitis, and organ diseases (such as those related to the heart, liver,kidney, lung, intestine and pancreas). Living donors should be over the age of 18 years and compatible with the intended transplant candidate. The donors are screened from medical and psychosocial aspects.

Deceased donor (cadaver donor or Brain Dead Donor)

  • A deceased donor is an individual who has been declared brain dead
  • Death is confirmed when a person's heart has permanently ceased beating
  • A person is considered deceased when brain death occurs, even if the heart continues to beat. The heart may continue to function for several hours or days. During this time, with the family's consent, various organs and tissues can be donated for transplantation.

Registration for a cadaver organ can be done through the Zonal Transplant Coordination Committee (ZTCC) by working with the hospital's transplant coordinator and nephrologist to be added to the city waiting list.

How long do you have to be hospitalized post transplantation?

The donor is admitted 1 day prior and the recipient is admitted 2 days prior to the scheduled date of transplantation. The approximate duration of stay in the hospital for a donor is 3-5 days and that for the recipient is 7-10 days.

What is the success rate of kidney transplantation?

Overall, transplant success rates are very good. Transplants from deceased donors have a success rate of 85 to 90% in the first year, meaning that 85 to 90 out of 100 transplanted kidneys continue to function after one year. Transplants from live donors have a slightly higher success rate, ranging from 90 to 95%. Long term success is good for people of all ages.

The Nephrology and Urology departments are home to one of the city's largest dialysis centres and a robust renal transplant program, successfully conducting both living and cadaveric transplants. With strict infection control measures, well-established immunosuppressive protocols, and proactive monitoring for complications, the service is on par with leading medical facilities. The Transplant Unit also takes a comprehensive approach to care, addressing the health needs of both the transplant patient and their family through careful analysis and integrated support.

State-of-the-art procedures for Kidney Transplantation include:

  • Living Donor Kidney Transplants
  • Cadaver Donor Kidney Transplantation
  • ABO-Incompatible Transplantation
  • Paired Kidney Exchanges
  • Laparoscopic Donor Nephrectomy

The Kokilaben Hospital Kidney Transplantation Team comprises of specialists in transplantation medicine and surgery in India. The team comprises of 2 nephrologists, 1 transplant coordinator and 2 transplant surgeons.