Platelets are small blood cells that help the body form clots and prevent bleeding profusely and continuously. If there is damage to one of the blood vessels, the platelets are activated, which then rush to the site of damage and fix it by forming a platelet plug.
The process by which platelets spread across the damaged blood vessel’s surface is known as adhesion. When platelets reach the site of damage, they stick to one another and also send out signals to gather more platelets, by a process called aggregation. Platelets are extremely important to the process of stoppage of bleeding.
A healthy platelet count ranges from 150,000 to 400,000 platelets/mcl of blood. If someone has a platelet count of less than 150,000, the condition is referred to as thrombocytopenia. On the other hand, a platelet count of more than 400,000 is referred to as thrombocytosis. The platelet count is determined by a routine blood test known as complete blood count (CBC). There are many diseases that are linked to a decreased platelet count. All of these conditions are associated with failure of clot formation which manifests in the form of continuous bleeding. As such, these patients require platelet transfusions.
Following are some medical conditions associated with abnormal platelets or abnormal platelet counts:
Thrombocytopenia: When the bone marrow produces too few platelets or too many platelets are destroyed, the condition is called thrombocytopenia. If the platelet count falls too low than the normal levels, it can cause bleeding beneath the skin which presents in the form of bruises. Low platelet counts can also present in the form of internal bleeding or profuse, continuous bleeding through a cut in the skin.
Many factors can give rise to thrombocytopenia including several medications, liver disease, infections, pregnancy, and abnormal immune system.
The signs and symptoms of thrombocytopenia include:
If you notice signs and symptoms of thrombocytopenia that worry you, you must see a healthcare provider. If bleeding does not stop, it is a medical emergency. You must seek immediate help for bleeding that can’t be stopped by first-aid techniques.
Platelets are produced in the bone marrow. There are certain factors which contribute to decreased platelet production, including:
Certain conditions can make the body destroy platelets or use them up faster than they are produced. This causes a shortage of platelets in the bloodstream. Following are examples of such conditions:
When the platelet count falls below 10,000 platelets per microlitre, it gives rise to dangerous internal bleeding. Although it is rare, severe forms of thrombocytopenia can cause life-threatening bleeding in the brain.
Following are some eligibility criteria for Single Donor platelet donation:
Following are some eligibility criteria for blood donations:
The donor for platelet donation also undergoes a haemoglobin screening just like a blood donor does. A confidential medical history is taken and a physical examination is performed to check the vital parameters of the donor including blood pressure, temperature, pulse rate & haemoglobin level. Blood samples are collected from the donor and sent to the laboratory for some investigations including triple serology, complete blood count, and screening for malaria. The results are valid only for 7 days to 1 month. If platelepheresisis takes place after one month, the donors are tested again for the above parameters.
Some facts a platelet donor should know:
By donating platelets, you can have an immediate and powerful impact on the life of a cancer patient. Your platelets are transfused to a patient within a week and they could play a major role in keeping them alive. Platelets are mostly used for cancer patients, but also help patients with undergoing open-heart surgery and organ transplants or blood disorders. Because platelets need to be transfused within a week of collection, platelet donors are constantly needed to keep the supply stable.
If you are looking for a centre for platelet transfusion in Indore, you can visit the Blood Centre and Transfusion Medicine Department at Kokilaben Dhirubhai Ambani Hospital, Indore and seek help. Our department is equipped with state-of-the-art infrastructure and advanced medical instruments. Our staff members are highly qualified and experienced and deliver all services with utmost care and professionalism. International protocols and quality standards are followed during all the procedures. You can also visit our team for platelet donation in Indore.